Leucoderma is an acquired disease in which the melanocytes in localized areas of the body stop producing melanin.Clinically it manifests as macular areas of depigmentation.Occassionally,the skin in certain areas may only be hypopigmented.There is no other change in the skin.In some lesions,hair may also become depigmented.This is called leucotrichia.The lesions vary in shape and size and may appear on any part of the skin and mucous membranes.the extent of involvement may vary from a single macule to involvement of almost the entire skin and mucous membranes.The progression of disease is variable.The disease may show a gradual extension or remain static for prolonged periods with occasional exacerbations.

Leucoderma is a chronic skin disease that causes loss of pigment, resulting in irregular pale patches of skin. It occurs when the melanocytes, cells responsible for skin pigmentation, die or are unable to function. The precise cause of vitiligo is complex and not fully understood. There is some evidence suggesting it is caused by a combination of auto-immune, genetic, and environmental factors.